Detecting association of rare and common variants based on cross-validation prediction error
نویسندگان
چکیده
منابع مشابه
Detecting association with rare variants for common diseases using haplotype-based methods
Current Genome-Wide Association Studies (GWAS) have successfully detected many genetic variants contributing to common diseases but not rare ones. Here two haplotypebased methods are proposed for detecting rare variants contributing a common disease. One method is a haplotypebased truncated product method (HTPM), for which we borrow a p-value combination method from testing for the multiple hyp...
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Increasing evidence shows that complex diseases are caused by both common and rare variants. Recently, several statistical methods for detecting associations of rare variants have been developed, including the test for testing the effect of an optimally weighted combination of variants (TOW) developed by our group in 2012. These methodologies consider phenotype measurement at only one time poin...
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We compare the SNP-based and gene-based association studies using 697 unrelated individuals. The Benjamini-Hochberg procedure was applied to control the false discovery rate for all the multiple comparisons. We use a linear model for the single-nucleotide polymorphism (SNP) based association study. For the gene-based study, we consider three methods. The first one is based on a linear model, th...
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A number of studies have been conducted to investigate the predictive value of common genetic variants for complex diseases. To date, these studies have generally shown that common variants have no appreciable added predictive value over classical risk factors. New sequencing technology has enhanced the ability to identify rare variants that may have larger functional effects than common varian...
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Despite the success of genome-wide association studies (GWASs) in detecting common variants (minor allele frequency ≥0.05) many suggested that rare variants also contribute to the genetic architecture of diseases. Recently, researchers demonstrated that rare variants can show a strong stratification which may not be corrected by using existing methods. In this paper, we focus on a case-parents ...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2017
ISSN: 0741-0395
DOI: 10.1002/gepi.22034